How Long Does SSRI Withdrawal Last?

Symptoms of SSRI withdrawal are usually mild, go away on their own, and last about one to two weeks.

SSRIs (selective serotonin reuptake inhibitors) are the most prescribed type of antidepressant medication. They work by blocking some reuptake of serotonin, helping to elevate mood. 

Examples of SSRIs include:

• Fluoxetine (Prozac Weekly, Prozac, Sarafem)
• Citalopram (Celexa)
• Sertraline (Zoloft)
• Paroxetine (Paxil, Pexeva, Paxil CR)
• Escitalopram (Lexapro)

When people stop taking SSRIs and other antidepressants, they can have withdrawal symptoms, called antidepressant discontinuation syndrome. This is commonly seen with SSRI discontinuation, because SSRIs are the most commonly prescribed class of antidepressant. 

Withdrawal symptoms usually occur within three days of stopping SSRIs or initiating a medication taper, but in some people, reactions may occur within hours of the first missed dose.

Symptoms of withdrawal are usually mild, go away on their own, and last about one to two weeks.